Division for Small Animal MRI

We support research involving MRI measurements.

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Preclinical 7T MRI/MRS System: BioSpec 70/20 USR (Bruker BioSpin)

Measurement Target

Experimental small animals (mice and rats), excised organs or tissues, fixed specimens, cell suspensions, and solution samples.

How to Use

Please send your inquiries to our email address. We will proceed after an initial consultation regarding the research content and MRI measurements.

Usage Fee

Charges for MRI measurements

Affiliated with the Graduate School of Medicine, Kyoto University
Isoflurane Not Used: ¥3,800 per hour
Isoflurane Used: ¥4,600 per hour
Affiliated with Kyoto University (outside the Grad. School of Med.)
Isoflurane Not Used: ¥5,300 per hour
Isoflurane Used: ¥6,100 per hour
Outside Kyoto University
Isoflurane Not Used: ¥7,300 per hour
Isoflurane Used: ¥8,100 per hour

Access

School of Human Health Sciences, North Building Basement, Faculty of Medicine, University Hospital, West Campus, Yoshida Campus

Contact

Phone: 075-751-3955
E-mail: preclinical_mri(at)support-center.med.kyoto-u.ac.jp
(* When sending an email, please replace (at) with @.)

Achievements

Publications

2024

Human trapezius muscle development during the early fetal period. Iwasa Y, Kanahashi T, Imai H, Otani H, Yamada S, Takakuwa T. J Anat. 2024 Jul 29. doi: 10.1111/joa.14116. Online ahead of print.
Formation of tendinous intersections in the human fetal rectus abdominis. Iwasa Y, Kanahashi T, Matsubayashi J, Imai H, Otani H, Yamada S, Takakuwa T. J Anat. 2024 Sep;245(3):365-376. doi: 10.1111/joa.14064. Epub 2024 May 29.
In vivo and post-mortem comparisons of IVIM/time-dependent diffusion imaging parameters in melanoma and breast cancer xenograft models. Someya Y, Iima M, Imai H, Isoda H, Ohno T, Kataoka M, Le Bihan D, Nakamoto Y. Magn Reson Med Sci. 2024 May 25. doi: 10.2463/mrms.mp.2023-0078. Online ahead of print.
Sexual dimorphism of the human fetal pelvis exists at the onset of primary ossification. Kanahashi T, Matsubayashi J, Imai H, Yamada S, Otani H, Takakuwa T. Commun Biol. 2024 May 7;7(1):538. doi: 10.1038/s42003-024-06156-y.
Regional differences in the umbilical vein and ductus venosus at different stages of normal human development. Isotani N, Kanahashi T, Imai H, Yoneyama A, Yamada S, Takakuwa T. Anat Rec (Hoboken). 2024 Mar 9. doi: 10.1002/ar.25421. Online ahead of print.
Pyramidalis muscle formation during human embryonic and early fetal periods. Iwasa Y, Kanahashi T, Imai H, Otani H, Yamada S, Takakuwa T. Congenit Anom (Kyoto). 2024 Mar;64(2):32-39. doi: 10.1111/cga.12551. Epub 2024 Jan 26. [Cover image]

2023

KUS121, a VCP modulator, has an ameliorating effect on acute and chronic heart failure without calcium loading via maintenance of intracellular ATP levels. Tsuji S, Otani C, Horie T, Watanabe S, Baba O, Sowa N, Ide Y, Kashiwa A, Makiyama T, Imai H, Nakashima Y, Yamasaki T, Xu S, Matsushita K, Suzuki K, Zou F, Kume E, Hasegawa K, Kimura T, Kakizuka A, Ono K. Biomed Pharmacother. 2024 Jan;170:115850. doi: 10.1016/j.biopha.2023.115850. Epub 2023 Dec 12.
Morphogenesis of the pulmonary vein and left atrial appendage in human embryos and early fetuses. Fukui N, Kanahashi T, Matsubayashi J, Imai H, Yoneyama A, Otani H, Yamada S, Takakuwa T. J Anat. 2024 Jan;244(1):142-158. doi: 10.1111/joa.13941. Epub 2023 Aug 9.
Femoral posture during embryonic and early fetal development: An analysis using landmarks on the cartilaginous skeletons of ex vivo human specimens. Takakuwa T, Saizonou MA, Fujii S, Kumano Y, Ishikawa A, Aoyama T, Imai H, Yamada S, Kanahashi T. PLoS One. 2023 May 2;18(5):e0285190. doi: 10.1371/journal.pone.0285190. eCollection 2023.

2022

Tentorium cerebelli formation during human embryonic and early fetal development. Matsunari C, Kanahashi T, Otani H, Imai H, Yamada S, Okada T, Takakuwa T. Anat Rec (Hoboken). 2023 Mar;306(3):515-526. doi: 10.1002/ar.25110. Epub 2022 Nov 16.
Thioredoxin deficiency increases oxidative stress and causes bilateral symmetrical degeneration in rat midbrain. Ohmori I, Ouchida M, Imai H, Ishida S, Toyokuni S, Mashimo T. Neurobiol Dis. 2022 Dec;175:105921. doi: 10.1016/j.nbd.2022.105921. Epub 2022 Nov 11.
Three-dimensional visualization and quantitative analysis of embryonic and fetal thigh muscles using magnetic resonance and phase-contrast X-ray imaging. Yamaguchi Y, Murase A, Kodama R, Yamamoto A, Imai H, Yoneyama A, Yamada S. J Anat. 2022 Dec;241(6):1310-1323. doi: 10.1111/joa.13764. Epub 2022 Sep 19.
Three-dimensional morphogenesis of the human diaphragm during the late embryonic and early fetal period: Analysis using T1-weighted and diffusion tensor imaging. Kanahashi T, Imai H, Otani H, Yamada S, Yoneyama A, Takakuwa T. J Anat. 2023 Jan;242(2):174-190. doi: 10.1111/joa.13760. Epub 2022 Sep 2. [Cover image]
Morphometric analysis of secondary palate development in human embryos. Nohara A, Owaki N, Matsubayashi J, Katsube M, Imai H, Yoneyama A, Yamada S, Kanahashi T, Takakuwa T. J Anat. 2022 Dec;241(6):1287-1302. doi: 10.1111/joa.13745. Epub 2022 Aug 19.
Excess intracellular ATP causes neuropathic pain following spinal cord injury. Nakajima N, Ohnishi Y, Yamamoto M, Setoyama D, Imai H, Takenaka T, Matsumoto M, Hosomi K, Saitoh Y, Furue H, Kishima H. Cell Moll Life Sci. 2022 Aug 16;79(9):483. doi: 10.1007/s00018-022-04510-z.
Evolutionary loss of complexity in human vocal anatomy as an adaptation for speech. Nishimura T, Tokuda IT, Miyachi S, Dunn JC, Herbst CT, Ishimura K, Kaneko A, Kinoshita Y, Koda H, Saers JPP, Imai H, Matsuda T, Larsen ON, Jürgens U, Hirabayashi H, Kojima S, Fitch WT. Science. 2022 Aug 12;377(6607):760-763. doi: 10.1126/science.abm1574. Epub 2022 Aug 11.
The bifurcation angle is associated with the progression of saccular aneurysms. Shimizu K, Kataoka H, Imai H, Miyata T, Okada A, Sakai N, Chin M, Iwasaki K, Hatano T, Imamura H, Ishibashi R, Goto M, Koyanagi M, Aoki T, Miyamoto S. Sci. Rep. 2022 May 6;12(1):7409. doi: 10.1038/s41598-022-11160-5.
Investigation of breast cancer microstructure and microvasculature from time-dependent DWI and CEST in correlation with histological biomarkers. Someya Y, Iima M, Imai H, Yoshizawa A, Kataoka M, Isoda H, Le Bihan D, Nakamoto Y. Sci Rep. 2022 Apr 20;12(1):6523. doi: 10.1038/s41598-022-10081-7.

2021

Therapeutic potential of clinical-grade human induced pluripotent stem cell-derived cardiac tissues. Osada H, Kawatou M, Fujita D, Tabata Y, Minatoya K, Yamashita JK, Masumoto H. JTCVS Open. 2021 Dec;8:359-374. doi: 10.1016/j.xjon.2021.09.038.
Upper arm posture during human embryonic and fetal development. Kumano Y, Tanaka S, Sakamoto R, Kanahashi T, Imai H, Yoneyama A, Yamada S, Takakuwa T. Anat Rec (Hoboken). 2022 Jun;305:1682-1691. doi: 10.1002/ar.24796. Epub 2021 Oct 3.
Fluid dynamics analyses of the intrahepatic portal vein tributaries using 7-T MRI. Oshima Y, Ogiso S, Imai H, Nakamura M, Wakama S, Tomofuji K, Ito T, Fukumitsu K, Ishii T, Matsuda T, Taura K. HPB (Oxford). 2021 Nov;23(11):1692-1699. doi: 10.1016/j.hpb.2021.04.005. Epub 2021 Apr 16.
Induction of CCN1 in Growing Saccular Aneurysms: A Potential Marker Predicting Unstable Lesions. Shimizu K, Imai H, Kawashima A, Okada A, Ono I, Miyamoto S, Kataoka H, Aoki T. J Neuropathol Exp Neurol. 2021 Aug 11;80(7):695-704. doi: 10.1093/jnen/nlab037.
A 3D analysis of growth trajectory and integration during early human prenatal facial growth. Katsube M, Yamada S, Utsunomiya N, Yamaguchi Y, Takakuwa T, Yamamoto A, Imai H, Saito A, Vora SR, Morimoto N. Sci Rep. 2021 Mar 25;11(1):6867. doi: 10.1038/s41598-021-85543-5.
Morphology and morphometry of the human early fetal brain: A three-dimensional analysis. Takakuwa T, Shiraishi N, Terashima M, Yamanaka M, Okamoto I, Imai H, Ishizu K, Yamada S, Ishikawa A, Kanahashi T. J Anat. 2021 Aug;239(2):498-516. doi: 10.1111/joa.13433. Epub 2021 Mar 23.
Hemodynamic Force as a Potential Regulator of Inflammation-Mediated Focal Growth of Saccular Aneurysms in a Rat Model. Shimizu K, Kataoka H, Imai H, Yamamoto Y, Yamada T, Miyata H, Koseki H, Abekura Y, Oka M, Kushamae M, Ono I, Miyamoto S, Nakamura M, Aoki T. J Neuropathol Exp Neurol. 2021 Jan 1;80(1):79-88. doi: 10.1093/jnen/nlaa131. [Cover image]

2020

Photoacoustic in vivo 3D imaging of tumor using a highly tumor-targeting probe under high-threshold conditions. Yamada H, Matsumoto N, Komaki T, Konishi H, Kimura Y, Son A, Imai H, Matsuda T, Aoyama Y, Kondo T. Sci Rep. 2020 Nov 9;10(1):19363. doi: 10.1038/s41598-020-76281-1.
Development of Helical Myofiber Tracts in the Human Fetal Heart: Analysis of Myocardial Fiber Formation in the Left Ventricle From the Late Human Embryonic Period Using Diffusion Tensor Magnetic Resonance Imaging. Nishitani S, Torii N, Imai H, Haraguchi R, Yamada S, Takakuwa T. J Am Heart Assoc. 2020 Oct 20;9(19):e016422. doi: 10.1161/JAHA.120.016422. Epub 2020 Sep 30.
Shoulder girdle formation and positioning during embryonic and early fetal human development. Tanaka S, Sakamoto R, Kanahashi T, Yamada S, Imai H, Yoneyama A, Takakuwa T. PLoS One. 2020 Sep 11;15(9):e0238225. doi: 10.1371/journal.pone.0238225. eCollection 2020.
Hemodynamic and Histopathological Changes in the Early Phase of the Development of an Intracranial Aneurysm. Kataoka H, Yagi T, Ikedo T, Imai H, Kawamura K, Yoshida K, Nakamura M, Aoki T, Miyamoto S. Neurol Med Chir (Tokyo). 2020 Jul 15;60(7):319-328. doi: 10.2176/nmc.st.2020-0072. Epub 2020 Jun 12.
Dedifferentiation of smooth muscle cells in intracranial aneurysms and its potential contribution to the pathogenesis. Oka M, Shimo S, Ohno N, Imai H, Abekura Y, Koseki H, Miyata H, Shimizu K, Kushamae M, Ono I, Nozaki K, Kawashima A, Kawamata T, Aoki T. Sci Rep. 2020 May 20;10(1):8330. doi: 10.1038/s41598-020-65361-x.
Relationship between rectal abdominis muscle position and physiological umbilical herniation and return: A morphological and morphometric study. Ji X, Ishikawa A, Nagata A, Yamada S, Imai H, Matsuda T, Takakuwa T. Anat Rec (Hoboken). 2020 Dec;303(12):3044-3051. doi: 10.1002/ar.24358. Epub 2020 Jan 15.

2019

Microglia-Triggered Plasticity of Intrinsic Excitability Modulates Psychomotor Behaviors in Acute Cerebellar Inflammation. Yamamoto M, Kim M, Imai H, Itakura Y, Ohtsuki G. Cell Rep. 2019 Sep 10;28(11):2923-2938.e8. doi: 10.1016/j.celrep.2019.07.078. [Cover figure]
Morphogenesis of the femur at different stages of normal human development. Suzuki Y, Matsubayashi J, Ji X, Yamada S, Yoneyama A, Imai H, Matsuda T, Aoyama T, Takakuwa T. PLoS One. 2019 Aug 23;14(8):e0221569. doi: 10.1371/journal.pone.0221569. eCollection 2019.
Vasa vasorum formation is associated with rupture of intracranial aneurysms. Miyata H, Imai H, Koseki H, Shimizu K, Abekura Y, Oka M, Kawamata T, Matsuda T, Nozaki K, Narumiya S, Aoki T. J Neurosurg. 2020 Sep;133(3):789-799. doi: 10.3171/2019.5.JNS19405. Epub 2019 Aug 16.
Position of the cecum in the extraembryonic and abdominal coelom in the early fetal period. Nagata A, Hatta S, Imai H, Yamada S, Takakuwa T. Congenit Anom (Kyoto). 2020 May;60(3):87-88. doi: 10.1111/cga.12348. Epub 2019 Jul 23.
Sequential Inward Bending of Arterial Bifurcations is Associated with Intracranial Aneurysm Formation. Ikedo T, Kataoka H, Minami M, Hayashi K, Miyata T, Nagata M, Fujikawa R, Yokode M, Imai H, Matsuda T, Miyamoto S. World Neurosurg. 2019 Sep;129:e361-e366. doi: 10.1016/j.wneu.2019.05.153. Epub 2019 Jun 6.
3D Scanning Technology Bridging Microcircuits and Macroscale Brain Images in 3D Novel Embedding Overlapping Protocol. Ide S, Kajiwara M, Imai H, Shimono M. J Vis Exp. 2019 May 12;(147). doi: 10.3791/58911.
Spatial Relationship Between the Metanephros and Adjacent Organs According to the Carnegie Stage of Development. Ishiyama H, Ishikawa A, Imai H, Matsuda T, Yoneyama A, Yamada S, Takakuwa T. Anat Rec (Hoboken). 2019 Nov;302(11):1901-1915. doi: 10.1002/ar.24103. Epub 2019 Mar 18.
Critical Growth Processes for the Midfacial Morphogenesis in the Early Prenatal Period. Katsube M, Yamada S, Yamaguchi Y, Takakuwa T, Yamamoto A, Imai H, Saito A, Shimizu A, Suzuki S. Cleft Palate Craniofac J. 2019 Sep;56(8):1026-1037. doi: 10.1177/1055665619827189. Epub 2019 Feb 17.
Size-tunable MRI-visible nitroxide-based magnetic mixed micelles: preparation, stability, and theranostic application. Nagura K, Bogdanov A, Chumakova N, Vorobiev AK, Moronaga S, Imai H, Matsuda T, Noda Y, Maeda T, Koizumi S, Sakamoto K, Amano T, Yoshino F, Kato T, Komatsu N, Tamura R. Nanotechnology. 2019 May 31;30(22):224002. doi: 10.1088/1361-6528/ab0627. Epub 2019 Feb 11.
Return of the intestinal loop to the abdominal coelom after physiological umbilical herniation in the early fetal period. Nagata A, Hatta S, Ji X, Ishikawa A, Sakamoto R, Yamada S, Imai H, Matsuda T, Takakuwa T. J Anat. 2019 Apr;234(4):456-464. doi: 10.1111/joa.12940. Epub 2019 Jan 25.
Magnetic Mixed Micelles Composed of a Non-Ionic Surfactant and Nitroxide Radicals Containing a D-Glucosamine Unit: Preparation, Stability, and Biomedical Application. Nagura K, Takemoto Y, Yoshino F, Bogdanov A, Chumakova N, Vorobiev AK, Imai H, Matsuda T, Shimono S, Kato T, Komatsu N, Tamura R. Pharmaceutics. 2019 Jan 19;11(1):42. doi: 10.3390/pharmaceutics11010042.

2018

Effects of diffusion time on non-Gaussian diffusion and intravoxel incoherent motion (IVIM) MRI parameters in breast cancer and hepatocellular carcinoma xenograft models. Iima M, Nobashi T, Imai H, Koyasu S, Saga T, Nakamoto Y, Kataoka M, Yamamoto A, Matsuda T, Togashi K. Acta Radiol Open. 2018 Jan 11;7(1):2058460117751565. doi: 10.1177/2058460117751565. eCollection 2018 Jan.
Formation of the Periotic Space During the Early Fetal Period in Humans. Ishikawa A, Ohtsuki S, Yamada S, Uwabe C, Imai H, Matsuda T, Takakuwa T. Anat Rec (Hoboken). 2018 Apr;301(4):563-570. doi: 10.1002/ar.23764. Epub 2018 Jan 18.
Morphogenesis of the Middle Ear during Fetal Development as Observed Via Magnetic Resonance Imaging. Ohtsuki S, Ishikawa A, Yamada S, Imai H, Matsuda T, Takakuwa T. Anat Rec (Hoboken). 2018 May;301(5):757-764. doi: 10.1002/ar.23760. Epub 2018 Jan 23.

2017

Quantitation of nasal development in the early prenatal period using geometric morphometrics and MRI: a new insight into the critical period of Binder phenotype. Katsube M, Yamada S, Miyazaki R, Yamaguchi Y, Makishima H, Takakuwa T, Yamamoto A, Fujii Y, Morimoto N, Ito T, Imai H, Suzuki S. Prenat Diagn. 2017 Sep;37(9):907-915. doi: 10.1002/pd.5106. Epub 2017 Aug 1. [Cover image]
Three-dimensional models of the segmented human fetal brain generated by magnetic resonance imaging. Yamaguchi Y, Miyazaki R, Kamatani M, Uwabe C, Makishima H, Nagai M, Katsube M, Yamamoto A, Imai H, Kose K, Togashi K, Yamada S. Congenit Anom (Kyoto). 2018 Mar;58(2):48-55. doi: 10.1111/cga.12229. Epub 2017 Jun 28. [Cover image]
Cartilage formation in the pelvic skeleton during the embryonic and early-fetal period. Okumura M, Ishikawa A, Aoyama T, Yamada S, Uwabe C, Imai H, Matsuda T, Yoneyama A, Takeda T, Takakuwa T. PLoS One. 2017 Apr 6;12(4):e0173852. doi: 10.1371/journal.pone.0173852. eCollection 2017.
Positional Changes of the Ocular Organs During Craniofacial Development. Osaka M, Ishikawa A, Yamada S, Uwabe C, Imai H, Matsuda T, Yoneyama A, Takeda T, Takakuwa T. Anat Rec (Hoboken). 2017 Dec;300(12):2107-2114. doi: 10.1002/ar.23588. Epub 2017 May 2.

International Conference Presentations