【ASHBi SignAC】2026/1/14 ASHBi SignAC Technology Seminar - Optoproteomics: Enabling Nanoscopic Proteomic Discovery

Dear all,

This is an announcement of the ASHBi SignAC Technology Seminar on 14 January 2026 by Syncell Inc.

Please see the following details and kindly attend the seminar if you are interested.

Detail | https://ashbi.kyoto-u.ac.jp/event/event-techseminar/21433/
Registration | https://forms.gle/r9j4z1yhXJrbbV89A
(Deadline: Thursday, 8 January 2026)

◆ASHBi SignAC Technology Seminar – Syncell Microscoop -◆
Date: Wednesday, 14 January 2026

Schedule:
① 14:00–15:00 [English] — Webinar
② 15:00–16:00 [Japanese] — Hybrid (On-site & Online)
③ 16:00–16:30 — Individual Consultation Session

Venue: ① Webinar / ② Hybrid meeting / ③ On-site only
Conference Room (B1F, Faculty of Medicine Bldg. B), Kyoto University / Zoom Online
* On-site participation will be closed when capacity is reached.
* Highspeed LAN/WiFi environment advised for stability

Title: Optoproteomics: Enabling Nanoscopic Proteomic Discovery

Lecturer:
・Dr. Jung-Chi Liao (Founder & CEO, Syncell) (English Webinar Session)
・Mr. Satoshi Sagara (SCRUM Inc.) (Japanese Hybrid-seminar Session)

Eligibility: Researchers and students

Abstract: Microscopy-guided proteomic discovery at the nanoscopic (<100 nm) spatial precision is desired for revealing unknown protein constituents in specific disease- or functional-associated regions at the level of molecular-molecular interactions. Here, we achieve spatial protein purification by using Microscoop®, a firmware-integrated microscopy platform that triggers in situ subcellular photobiotinylation of proteins at user-defined regions of interest (ROIs), one field of view (FOV) at a time, for thousands of FOVs fully automatically. Sufficient proteins are biotinylated and pulled down from a cell, FFPE tissue, or fresh frozen tissue sample at up to 25-nm precision. Subsequent LC-MS/MS is implemented to reveal the subcellular proteome at high sensitivity, specificity, and spatial precision. Microscoop has been successfully used to identify novel protein constituents for subcellular organelles (stress granules, primary cilia), inter-organelle contact sites (mitochondria-lipid droplet contacts), surfaceome, aggregates/condensates (TDP-43 aggregates, amyloid β plagues, Polycomb repressive complex), cell proteomic subtyping (hippocampal vs cortical astrocytes), cell-cell interface (immune synapses), and others.

If you have any questions or inquiries, please do not hesitate to contact us.
We look forward to your participation in the seminar!

Sincerely yours,

Organizer: ASHBi SignAC, Kyoto University
Mail: ashbi-signac-office[*]mail2.adm.kyoto-u.ac.jp
Replace [*] to @.